Princesses Celestia and Luna are having some fun with Shakespearean quotes. Celestia is quoting from “Hamlet” while gazing upon Discord’s skull. If you are familiar with the play it may be more amusing, just maybe.
"They may tell you that with a friend like me, who needs enemies? But the truth is that with a friend like me, you’ll never have any."
From left to right, the pony as their respective Coon and Friends hero and the South Park character in parentheses:
-Rarity as The Human Kite (Kyle)
-Some-random-pony-I-haven’t-decided-on-yet as Mysterion (Kenny)
-Rainbow Dash as Toolshed (Stan)
-Fluttershy as The Coon (Cartman)
-Twilight Sparkle as TupperWear (Token)
-Applejack as Mosquito (Clyde)
-Pinkie Pie as Mint-Berry Crunch (Bradley)
-Derpy Hooves as Iron Maiden (Timmy)
MLP - Coon and Friends. Based off of: http://southparkstudios.mtvnimages.com/shared/downloads/images/season-14/1411/1411-coon-and-friends-press-image.jpg
Just three drawings I made for a “Pony Finding a Magic Flower” theme. Top image: Poison Joke. Bottom left: Heart’s Desire. Bottom right: a mandrake (from Harry Potter).